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Rosacea - Basics Also in this section: Rosacea Treatment : The Sansrosa Patent - Some New Possible Treatment Methods : Definitions : |
AnalogThe term "analog" refers to a chemical compound that is structurally similar to a parent compound and has chemical properties or pharmaceutical activity in common with the parent compound. Analogs include, but are not limited to, homologs, i.e., where the analog differs from the parent compound by one or more carbon atoms in series; positional isomers; compounds that differ by interchange of one or more atoms by a different atom, for example, replacement of a carbon atom with an oxygen, sulfur, or nitrogen atom; and compounds that differ in the identity of one or more functional groups, for example, the parent compound differs from its analog by the presence or absence of one or more suitable substituents. Suitable substituents include, but are not limited to, (C.sub.1-C.sub.8)alkyl; (C.sub.1-C.sub.8)alkenyl; (C.sub.1-C.sub.8)alkynyl: aryl; (C.sub.2-C.sub.5)heteroaryl; (C.sub.1-C.sub.6)heterocycloalkyl; (C.sub.3-C.sub.7)cycloalkyl; O--(C.sub.1-C.sub.8)alkyl; O--(C.sub.1-C.sub.8)alkenyl; O--(C.sub.1-C.sub.8)alkynyl; O-aryl; CN; OH; oxo; halo, C(O)OH; COhalo; O(CO)halo; CF.sub.3, N.sub.3; NO.sub.2, NH.sub.2; NH((C.sub.1-C.sub.8)alk- yl); N((C.sub.1-C.sub.8)alkyl).sub.2; NH(aryl); N(aryl).sub.2 N((C.sub.1-C.sub.8)alkyl)(aryl); (CO)NH.sub.2; (CO)NH((C.sub.1-C.sub.8)al- kyl); (CO)N((C.sub.1-C.sub.8)alkyl).sub.2; (CO)NH(aryl); (CO)N(aryl).sub.2; O(CO)NH.sub.2; NHOH; NOH((C.sub.1-C.sub.8)alkyl); NOH(aryl); O(CO)NH((C.sub.1-C.sub.8)alkyl); O(CO)N((C.sub.1-C.sub.8)alkyl- ).sub.2; O(CO)NH(aryl); O(CO)N(aryl).sub.2; CHO; CO((C.sub.1-C.sub.8)alkyl- ); CO(aryl); C(O)O((C.sub.1-C.sub.8)alkyl); C(O)O(aryl); O(CO)((C.sub.1-C.sub.8)alkyl); O(CO)(aryl); O(CO)O((C.sub.1-C.sub.8)alkyl- ); O(CO)O(aryl); S--(C.sub.1-C.sub.8)alkyl; S--(C.sub.1-C.sub.8)alkenyl; S--(C.sub.1-C.sub.8)alkynyl; S-aryl; S(O)C.sub.1-C.sub.8)alkyl; S(O)--(C.sub.1-C.sub.8)alkenyl; S(O)--(C.sub.1-C.sub.8)alkynyl; and S(O)-aryl; S(O).sub.2--(C.sub.1-C.sub.8)alkyl; S(O).sub.2--(C.sub.1-C.sub- .8)alkenyl; S(O).sub.2--(C.sub.1-C.sub.8)alkynyl; and S(O).sub.2-aryl. One of skill in the art can readily choose a suitable substituent based upon the stability and pharmacological activity of the compound of the invention. |
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